Picosecond fluctuating protein energy landscape mapped by pressure–temperature molecular dynamics simulation

Microscopic statistical pressure fluctuations can, in principle, lead to corresponding fluctuations in the shape of a protein energy landscape. To examine this, nanosecond molecular dynamics simulations of lysozyme are performed covering a range of temperatures and pressures. The well known dynamical transition with temperature is found to be pressure-independent, indicating that the effective energy barriers separating conformational substates are not significantly influenced by pressure. In contrast, vibrations within substates stiffen with pressure, due to increased curvature of the local harmonic potential in which the atoms vibrate. The application of pressure is also shown to selectively increase the damping of the anharmonic, low-frequency collective modes in the protein, leaving the more local modes relatively unaffected. The critical damping frequency, i.e., the frequency at which energy is most efficiently dissipated, increases linearly with pressure. The results suggest that an invariant description of protein energy landscapes should be subsumed by a fluctuating picture and that this may have repercussions in, for example, mechanisms of energy dissipation accompanying functional, structural, and chemical relaxation

Petrography and geochemistry of Palaeozoic quartz-rich sandstones from Saudi Arabia: implications for provenance and chemostratigraphy

The Arabian Peninsula hosts a thick Palaeozoic succession, ranging from the Cambrian through the Permian. It not only contains deposits of the two major Palaeozoic glaciations but also holds both the major Palaeozoic hydrocarbon source and reservoir rocks. In addition, Palaeozoic sandstones serve as important aquifers. The succession is dominated by highly mature quartz arenites, as seen in thin sections. It is starved of fossils and very uniform in lithology. In order to better understand provenance, tectonic setting and stratigraphic relationships, the petrography as well as major and trace element geochemistry of sandstones were studied. Samples were taken from two study areas in southern (Wajid area) as well as central and northern (Tabuk area) Saudi Arabia. The dataset we present here is the first comprehensive study to cover the entire Palaeozoic succession in both the southern and northern part of the Arabian Peninsula. The collisional signal from some samples is a relic from the last stages of the amalgamation of Gondwana, carried into the basin by glaciogenic sediments. Major and trace element geochemistry indicate the Neoproterozoic basement of the nearby Arabian Shield as the most likely source for the detritus. Tectonic discrimination diagrams suggest that deposition of sandstones took place in an intracratonic setting, which is in accordance with the established model for the evolution of the Arabian Plate. An influx of fresh material, probably sourced from the Shield, did occur in the late Palaeozoic units of the Wajid area but did not reach the Tabuk area. Geochemical methods have shown some success in characterising the provenance of both study areas but were unable to reliably assess sedimentary recycling. A (meta‐)sedimentary source for the Palaeozoic sandstones could therefore neither be proven nor refuted. Multivariate cluster and principal component analysis of geochemical data revealed significant differences between the two study areas

New insights into the provenance of Saudi Arabian Palaeozoic sandstones from heavy mineral analysis and single-grain geochemistry

Saudi Arabian Palaeozoic siliciclastics cover a stratigraphic range from the Cambrian to the Permian. They crop out along the eastern margin of the Arabian Shield and are comprised of highly mature sandstones. Their heavy mineral assemblage reflects their mineralogical maturity and is dominated by the ultra-stable phases zircon, tourmaline and rutile. Less stable accessories are apatite, staurolite and garnet. Standard heavy mineral analysis of samples from two study areas in central/northern (Tabuk area) and southern (Wajid area) Saudi Arabia reveals distinct changes in provenance. Cambrian–Ordovician sandstones are first-cycle sediments, probably sourced from the ‘Pan-African’ basement. The overlying Hirnantian glaciogenic deposits consist of recycled Cambrian–Ordovician material. Devonian–Permian sandstones show a significant influx of fresh basement material, as attested by an increase of meta-stable heavy minerals. Single-grain geochemical analysis of rutile and garnet has proven to be a powerful supplementary technique. Rutile varietal studies reveal distinct differences in host rock lithologies between the two study areas: the Tabuk area contains predominantly felsic rutiles, whereas the Wajid area has more mafic input. Zr-in-rutile thermometry identified granulite-facies detritus in the lower Palaeozoic of the Tabuk area and has the potential to further define source areas. The distribution patterns of garnet host rock lithologies are remarkably similar in both study areas. They are dominated by amphibolite-facies metasediments and intermediate to felsic igneous rocks. Garnets derived from granulite-facies metasediments, which are scarce in the Arabian–Nubian Shield, also occur. Possible source rocks for high-grade garnets can be found in Yemen or farther south in the Mozambique Belt

Technology Evaluation for Environmental Risk Mitigation Compendium

The Technology Evaluation for Environmental Risk Mitigation (TEERM) Principal Center and its predecessor organization the Acquisition Pollution Prevention Program (AP2) supported the National Aeronautics and Space Administration (NASA) in identifying technology solutions to risks and costs to NASA programs driven by environmental regulations and requirements. TEERM researched the commercial and government marketplace to locate viable and available technologies that met NASAs needs. TEERM focused on addressing environmentally-driven risks of direct concern to NASA programs and facilities, including hazardous materials in NASA operations and materials that became obsolescent because of environmental regulations. TEERM projects aimed to reduce cost; ensure the health and safety of people, assets, and the environment; promote efficiency; and minimize duplication. Major TEERM and AP2 projects focused on waste minimization and hazardous waste treatment, recycling, corrosion prevention and control, solvent and ozone depleting substances substitution, and aqueous based cleaners. In 2017, NASA made the decision to terminate the TEERM Principal Center. This Compendium Report documents TEERM and AP2 project successes. The Compendium Report traces the evolution of TEERM based on evolving risks and requirements for NASA and its relationship to the Space Shuttle Program, the United States Department of Defense, the European Space Agency, and other public and private stakeholders. This Compendium Report also documents project details from Project Summaries and Joint Test Plans and describes project stakeholders and collaborative effort results

Evolution of the Palaeotethys in the Eastern Mediterranean: A multi-method approach to unravel the age, provenance and tectonic setting of the Upper Palaeozoic Konya Complex and its Mesozoic cover sequence (south-central Turkey)

Thirteen siliciclastic sediments from the Upper Palaeozoic Konya Complex and its Mesozoic cover were studied by a multi-method approach combining thin-section petrography, bulk-rock geochemistry, mineral chemistry of rutile, and U–Pb geochronology of detrital zircons. Provenance sensitive data of samples from the Upper Palaeozoic Halıcı Formation indicate sediment supply from mainly low- to medium-grade metamorphosed sedimentary rocks of felsic character, while contribution from volcanic rocks was rare. The detrital zircon record of sediments from the Halıcı Formation documents sediment supply from different sources and excludes a similar provenance. Some samples show great similarities with Palaeozoic sandstones from the cover sequence of the Saharan Metacraton and the Arabian–Nubian Shield, while the other samples indicate a provenance that must be sought in units with a southern Eurasian affinity. The upper limit for sediment deposition in the Halıcı Formation is mostly constrained by Early Palaeozoic zircon populations, however, sediment accumulation in Pennsylvanian–Cisuralian time is more likely, contemporaneously with the Upper Palaeozoic succession on the Karaburun Peninsula (western Turkey). The provenance of sediments from the Upper Triassic Ardıçlı Formation remains enigmatic, but the source should be sought nonetheless in units close to the depositional site. In any case, detrital zircon age spectra and compositional data exclude recycling of underlying rock units (i.e. Halıcı Formation). Overall, our new provenance data reveal great similarities between the Konya Complex and comparable units (Chios, Karaburun) but also highlight distinct differences in terms of sediment composition and provenance

A Spin Modulated Telescope to Make Two Dimensional CMB Maps

We describe the HEMT Advanced Cosmic Microwave Explorer (HACME), a balloon borne experiment designed to measure sub-degree scale Cosmic Microwave Background anisotropy over hundreds of square degrees, using a unique two dimensional scanning strategy. A spinning flat mirror that is canted relative to its spin axis modulates the direction of beam response in a nearly elliptical path on the sky. The experiment was successfully flown in February of 1996, achieving near laboratory performance for several hours at float altitude. A map free of instrumental systematic effects is produced for a 3.5 hour observation of 630 square degrees, resulting in a flat band power upper limit of (l(l+1)C_l/2 pi)^0.5 < 77 microK at l = 38 (95% confidence). The experiment design, flight operations and data, including atmospheric effects and noise performance, are discussed.Comment: 4 pages, 3 figure